How a promising new Alzheimer’s treatment could revolutionise how we treat the disease

A game-changing new therapy that may potentially restore brain function in people with Alzheimer’s could soon be trialed on patients after a medical technology start-up company secured a license to develop the treatment.

The new ultrasound therapy, developed by University of Queensland’s (UQ) Prof. Jürgen Götz, will be refined through clinical trials by Ceretas and the company will aim to prove its effectiveness for Alzheimer’s and other neurodegenerative diseases.

Prof. Jürgen Götz explained that the ultrasound therapy uses sound waves to stimulate the brain, which helps improve communication between brain cells and clear harmful proteins associated with Alzheimer’s.

“The therapy increases neuronal signalling and thereby restores memory and cognition by enhancing communication between brain cells,” Prof. Götz said.

“But it also targets and clears the build-up of the proteins toxic amyloid and tau by activating the brain’s intrinsic clearance mechanism.”

Globally more than 55 million people have dementia and that number increases by 10 million new cases each year, according to the World Health Organisation (WHO). Alzheimer’s is the most common form of the disease and WHO estimates it may contribute to 60 to 70 per cent of overall dementia cases.

Prof. Götz said while current medications can slow down the disease and its symptoms, none offer patients a cure.

“Therapeutic ultrasound offers a non-invasive way of enhancing cognition,” he said.

“The treatment could also potentially be personalised across multiple neurological disorders including frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), disorders caused by brain tumours and mental disorders.”

The first human clinical safety trial of the new ultrasound medical device was successfully completed in 2024, led by UQ clinician-researcher Prof. Peter Nestor.

The trial results are expected to be published in early 2025.

While the ultrasound therapy offers hope for Alzheimer’s patients, other research highlights lifestyle changes that may help prevent the disease.

A study led by researchers at Rush University Medical Center in Chicago has suggested that a change in diet has the potential to reduce the risk of Alzheimer’s disease – the most common types of dementia – by up to 53 per cent

Known as the MIND (Mediterranean-DASH Intervention for Neurodegenerative Delay) diet, the results indicated that people who ate the foods included in the diet had the potential to improve their cognitive function, so much so that their mental powers were measured at up to 7.5 years younger than they would have been without the foods.

The diet basically consists of 10 foods that are healthy for the brain, as well as five that should be avoided where possible and include:

Nuts

While it can be easy to reach for a bag of chips or biscuits when you’re feeling peckish, nuts are often healthier and better for your brain. Where possible, opt for unsalted nuts such as walnuts, almonds, hazelnuts and peanuts. The MIND diet suggests eating them around five times a week.

Whole grains

When it comes to whole grains, research suggests that they’re something people should be eating three times a day. Many people opt for whole-grain bread over white slices, eating salads such as tabbouleh, which contains grain or swapping out white rice for gains such as barley, brown rice, bulgur, millet or quinoa.

Poultry and Fish

You may have heard that fish is great for the brain and the MIND diet confirms that this is true. While other diets suggest eating it several times a week, including fish in your diet for just one meal every seven days could make all the difference when it comes to your brain health, according to the new research. Poultry such as chicken and turkey is also recommended. People should eat it twice a week to get the full benefits.

Green vegetables

Vegetables such as broccoli, spinach and kale are loaded with vital vitamins and nutrients. While including them into your diet as little as two times a week can have a positive impact, servings of six or more each week have the potential to increase brain function and reduce the risks associated with Alzheimer’s disease.

In addition to your greens, salads and other veggies should also be included in your diet daily.

Berries

While all kinds of fruit can be great for health, the MIND diet specifically suggests berries to assist brain function. Blueberries and strawberries have been known to have a positive impact when eaten two times a week. Eat them alone or add them to cereal or other snacks during the day.

Beans

They may have some unfortunate side effects on your digestive system, but beans are another superfood when it comes to brain health. In addition to being full of fibre and protein, beans can assist with memory when eaten three times a week.

Wine

If you’re a lover of wine, this will be music to your ears. Drinking a glass of wine a day has the potential to work with other brain healthy foods. Be sure to limit yourself though, as too much can have a negative impact.

Olive oil

While it’s not always possible to cook with olive oil, the MIND diet recommends that using it could have the biggest impact when it comes to protecting against cognitive disease. Where you can, make the switch to olive oil – if not as a cooking oil, then perhaps in a salad dressing.

Foods to avoid

While there are foods that can help, there are also some that can cause problems. Red meat shouldn’t be consumed more than four times a week, while people aren’t recommended to eat more than a tablespoon of butter per day. Cheese should also be limited to once a week, with sweet pastries and other sweets only recommended in moderation.

IMPORTANT LEGAL INFO This article is of a general nature and FYI only, because it doesn’t take into account your personal health requirements or existing medical conditions. That means it’s not personalised health advice and shouldn’t be relied upon as if it is. Before making a health-related decision, you should work out if the info is appropriate for your situation and get professional medical advice.