New cancer therapy increasing rate of survival in patients

Pancreatic cancer often does not cause any signs or symptoms and by the time it is detected it has already

Pancreatic cancer often does not cause any signs or symptoms and by the time it is detected it has already reached a very advanced stage in most case, which is why pancreatic cancers are regarded as the cancer type with the lowest survival rate.

However, new research reveals there is a protein that helps pancreatic cancer avoid and then exploit the immune system and by using mice the researchers were able to demonstrate that blocking the protein could offer a way of stopping the spread of tumors and boost immunotherapy.

This latest revelation by the Beatson Institute in the United Kingdom comes hot on the heels of a clinical trial conducted by Cancer Research UK that shows pancreatic cancer patients have improved survival rates when employing a combined chemotherapy treatment instead of a standard treatment alone.

The Beatson team found that an important failure in the drugs used to attack pancreatic cancer has been the ability of tumors to surround themselves with a protective shield of proteins and cells that stop the primed immune cells from reaching and attacking the tumor.

By analysing the tumor tissue of pancreatic cancer patients who had undergone surgery the research team found high levels of the protein called CXCR2 and that a higher level of that protein correlated with a worse outcome for the patient.

The team went back to the mice and found those treated with an experimental drug that blocks the protein survived longer than those mice who were left untreated. They also found the inhibitor had a more powerful effect when combined with the chemotherapy drug gemcitabine.

The combination stopped the spread of tumors and allowed the T cells to break through the protective shield, which provided the opportunity to attack the tumor.

Have you been affected by cancer in any way? Share your thoughts with us.


  1. Hans  

    Prevention is better than treatment!
    On February 13, 2015, the American Cancer Society published their recommendations that
    cancer survivors should follow “prudent diets,” plant-based diets that are high in fruits, vege-
    tables and unrefined grains while at the same time being low in red and processed meats,
    refined grains, and sugars. Its report states, “These diets are in contrast to ‘Western’ diets,’
    which have the opposite pattern and are heavy in meats, sweets, other processed foods, and dietary fat.” They also recommend weight loss and exercise in order to prolong survival for
    people with cancer. This diet has been shown to positively affect survival in cancers of the:
    Skin: Melanoma
    *This research has been based on diets that are still too high in fat (30% or higher), loaded with animal foods, and deficient in plant-derived foods (especially starches).
    A truly low-fat, starch-based diet like the one once followed in Japan (rice and vege-
    tables with fewer than 10% of the calories as fat) would provide far greater benefits
    for prevention and survival than the “Mediterranean-type” diets that have been rec-
    ommended lately. A truly therapeutic diet, like the McDougall Diet, is 7% fat with no
    meat, poultry, fish, eggs, dairy, or vegetable oils.
    This dietary approach focuses on strengthening the human body and its magnificent abilities to heal and stay healthy; while, at the same time, removing cancer-causing and promoting elements from the patients’ diets.

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